Mechanistic insights into ultrasound-responsive implantable drug delivery systems
ultrasound for 5 min with 9.13° C increase as a safe operating condition. Under the selected setting, ultrasound significantly enhanced drug release for around 9.7-fold by accelerating drug dissolution and diffusion, without altering the structural properties of the release membrane. Collectively, these findings provide mechanistic insight into ultrasound-responsive reservoir implants and support their potential application in managing chronic conditions, where controllable, on-demand drug release is highly desirable.
Authors
- Yujie Lu (ORCID: https://orcid.org/0000-0002-9630-2390)
- Masoud Adhami
- Juan L. Paris (ORCID: https://orcid.org/0000-0001-8950-283X)
- Jiaqi Gao (ORCID: https://orcid.org/0000-0002-0376-3930)
- Mohammad Albraikat
- Eneko Larrañeta
- Huaidong Yang
Institutions
- Queen's University Belfast (GB)
- Zarqa University (JO)
- Karolinska Institutet (SE)
- Hospital Regional Universitario de Málaga (ES)
Publication Details
- Journal
- International Journal of Pharmaceutics
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1016/j.ijpharm.2026.126913
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department for the Economy
- Engineering and Physical Sciences Research Council