Evaluation of the predictive and prognostic potential of blood immune cell profiles in metastatic cancer patients treated with immune checkpoint inhibitors
memory T cell subsets, regardless of treatment response.In conclusion, elevated pre-treatment levels of blood monocytes, together with decreased levels lymphocytes, were associated with poor survival of ICI-treated patients. Although detailed immunophenotyping of pre-treatment blood immune cell populations showed limited predictive utility, specific subpopulations, such as intermediate monocytes and CD226⁺CD8⁺ memory T cells, may harbor potential as prognostic/predictive indicators.
Authors
- Outi Kuittinen (ORCID: https://orcid.org/0000-0001-9969-0053)
- Tuure Kinnunen (ORCID: https://orcid.org/0000-0003-1595-5371)
- Anna‐Mari Schroderus (ORCID: https://orcid.org/0000-0002-8517-0943)
- Satu Tiainen (ORCID: https://orcid.org/0000-0002-5673-8851)
- Sanna Suoranta
- Olli Tenhunen
- Tero Sievänen (ORCID: https://orcid.org/0000-0002-9660-4559)
- Veera Nurmela
- Anna Jokimäki
- Aino Rönkä
- Sanna Pasonen-Seppänen
Institutions
- University of Eastern Finland (FI)
- Oulu University Hospital (FI)
- Kuopio University Hospital (FI)
- Eastern Finland Laboratory Center (FI)
- Emergency Services College (FI)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1007/s00262-026-04404-0
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Itä-Suomen Yliopisto
- Suomen Kulttuurirahasto