<scp>QTc</scp> Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults
Summary Key points QTc interval prolongation affects nearly one‐third of hospitalized older adults, with 15.8% reaching the high‐risk threshold (> 500 ms). Polypharmacy with QTc‐prolonging drugs and diuretics is highly prevalent and represents a major, potentially modifiable risk factor. The Tisdale risk score reliably stratifies the risk of severe QTc prolongation in geriatric inpatients, even after adjustment for multimorbidity and renal dysfunction. Why does this matter? QTc prolongation is frequent yet under‐recognized in hospitalized older adults, exposing them to preventable life‐threatening arrhythmias. Routine use of the Tisdale score at admission can guide medication review and cardiac monitoring in geriatric practice.
Authors
- Rocco Micciolo (ORCID: https://orcid.org/0000-0002-8299-9879)
- Anna Giani (ORCID: https://orcid.org/0000-0001-6864-8653)
- Elena Zoico (ORCID: https://orcid.org/0000-0002-5235-1545)
- Gianluca Trifirò (ORCID: https://orcid.org/0000-0003-1147-7296)
- Sara Fiorini (ORCID: https://orcid.org/0000-0003-4864-4350)
- Francesco Fantin
- Mauro Zamboni
- Luana Giacobbe
Institutions
- University of Verona (IT)
- University of Trento (IT)
- Center for Neuroscience and Cognitive Systems (IT)
Publication Details
- Journal
- Journal of the American Geriatrics Society
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1111/jgs.70477
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona