<scp>QTc</scp> Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults

Summary Key points QTc interval prolongation affects nearly one‐third of hospitalized older adults, with 15.8% reaching the high‐risk threshold (&gt; 500 ms). Polypharmacy with QTc‐prolonging drugs and diuretics is highly prevalent and represents a major, potentially modifiable risk factor. The Tisdale risk score reliably stratifies the risk of severe QTc prolongation in geriatric inpatients, even after adjustment for multimorbidity and renal dysfunction. Why does this matter? QTc prolongation is frequent yet under‐recognized in hospitalized older adults, exposing them to preventable life‐threatening arrhythmias. Routine use of the Tisdale score at admission can guide medication review and cardiac monitoring in geriatric practice.

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Publication Details

Journal
Journal of the American Geriatrics Society
Published
2026-05-02
DOI
https://doi.org/10.1111/jgs.70477
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
0.00

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article

QTc Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults

Rocco Micciolo, Anna Giani, Elena Zoico, Gianluca Trifirò et al.
Journal of the American Geriatrics Society
Cardiac electrophysiology and arrhythmias
article

QTc Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults

Rocco Micciolo, Anna Giani, Elena Zoico, Gianluca Trifirò, Sara Fiorini, Francesco Fantin, Mauro Zamboni, Luana Giacobbe
article en

Abstract

Summary Key points QTc interval prolongation affects nearly one‐third of hospitalized older adults, with 15.8% reaching the high‐risk threshold (&gt; 500 ms). Polypharmacy with QTc‐prolonging drugs and diuretics is highly prevalent and represents a major, potentially modifiable risk factor. The Tisdale risk score reliably stratifies the risk of severe QTc prolongation in geriatric inpatients, even after adjustment for multimorbidity and renal dysfunction. Why does this matter? QTc prolongation is frequent yet under‐recognized in hospitalized older adults, exposing them to preventable life‐threatening arrhythmias. Routine use of the Tisdale score at admission can guide medication review and cardiac monitoring in geriatric practice.

Journal of the American Geriatrics Society
University of Verona (IT), University of Trento (IT), Center for Neuroscience and Cognitive Systems (IT)
Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona
Good health and well-being
Openalex Percentile: Top 12%
Cardiac electrophysiology and arrhythmias
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