A Triple-Stimuli-Responsive Photolabile Protecting Group Platform for Controlled Release
Photolabile protecting groups (PPGs) enable spatiotemporal control of chemical and biological processes, yet multistimuli-regulated systems remain rare. Here we report a triple-stimuli platform integrating light, base, and acid to control PPG release. Photoirradiation of diarylethenes (DAEs) under basic conditions generates stable 9,10-dihydrophenanthrene (9,10-DHP) intermediates that activate hemiaminal ethers and undergo acid-promoted aromatization to release the alcohol group. Distinct fluorescence changes allow real-time monitoring in both organic and aqueous media.
Authors
- Hebo Ye (ORCID: https://orcid.org/0000-0003-4964-984X)
- Lei You (ORCID: https://orcid.org/0000-0002-1649-803X)
- Guoshan Jiang
- J Huang
- Long Wang
Institutions
- Fujian Normal University (CN)
- Chinese Academy of Sciences (CN)
- Material (Belgium) (BE)
- Fujian Institute of Research on the Structure of Matter (CN)
- Tan Kah Kee Innovation Laboratory (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1021/acs.orglett.6c01180
- Primary Topic
- Photochromic and Fluorescence Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Natural Science Foundation of Fujian Province
- Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China