Skeletal Modification of Phenols into Benzo-Fused Seven-Membered N,O-Heterocycles via Catalytic Alkyl Nitrene C(sp <sup>2</sup> )–H Amination
)-H amination. The reaction is scalable with catalyst loadings as low as 0.1 mol %, enables solvent recovery, and allows for the late-stage annulation of diverse phenolic natural products and drug derivatives.
Authors
- Masakatsu Shibasaki (ORCID: https://orcid.org/0000-0001-8862-582X)
- Hidetoshi Noda (ORCID: https://orcid.org/0000-0001-6529-8870)
- Yasuko Asada
- Prasoon Raj Singh
Institutions
- Microbial Chemistry Research Foundation (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1021/acs.orglett.6c00993
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Takeda Science Foundation
- Fugaku Trust for Medicinal Research
- Japan Society for the Promotion of Science