Impact of Heavy Chain C‐Terminal Codons on Recombinant Monoclonal Antibody Expression Levels
was found to broadly influence the expression of other industrially relevant IgG mAb isotypes, including IgG2 and IgG4. This study establishes a connection between the HC C-terminal nucleotide sequence and mAb expression titer, offering insights for optimizing the expression of Fc-containing molecules.
Authors
- Ronan M. Kelly
- Sowmya Balasubramanian (ORCID: https://orcid.org/0009-0004-3386-8735)
- John Herrington
- Chris C Frye
- Kenneth R Carlson
Institutions
- Eli Lilly (United States) (US)
Publication Details
- Journal
- Biotechnology and Bioengineering
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1002/bit.70223
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company