Dual-modality imaging enables longitudinal biodistribution profiling of intracerebroventricular CAR-T therapy in orthotopic glioma
= 0.552, p < 0.001), supported by multi-organ pathological validation. Collectively, we establish a biocompatible dual-modality workflow that links intracranial anatomical localization with longitudinal whole-body biodistribution readouts for preclinical CAR-T tracking in solid tumor models.
Authors
- Chunzhao Li (ORCID: https://orcid.org/0000-0002-9983-3779)
- Na Xian (ORCID: https://orcid.org/0000-0001-7027-0418)
- Zhenhua Hu (ORCID: https://orcid.org/0000-0002-4600-3405)
- Gangxiong Huang (ORCID: https://orcid.org/0000-0002-0117-5457)
- Wenju Jiang (ORCID: https://orcid.org/0000-0003-1327-7159)
- Xiaobin Zhao
- P Zhang
- Nan Ji
- Rui Feng
- Yang Zhang
Institutions
- Fujian Medical University (CN)
- National Kidney Foundation (US)
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Peking University Cancer Hospital (CN)
- Shandong Institute of Automation (CN)
- Beijing Academy of Artificial Intelligence (CN)
- Beijing Advanced Sciences and Innovation Center (CN)
- Beihang University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1007/s00262-026-04403-1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Beijing Postdoctoral Science Foundation