Acarbose modulates microglial Pkm2 acetylation to reshape immunometabolism and preserve retinal neurons after ischemia-reperfusion
Cx3cr1-Cre mice conferred partial resistance to IR injury, but blunted the additional benefit of HY-113082 when combined with ACA, consistent with on-target engagement. Our findings support that ACA exerts retinal protection through the Sirt1-Pkm2-NAD axis, suggesting a metabolic checkpoint that integrates immune and mitochondrial regulation. This study provides mechanistic insight into ACA's dual immunometabolic and neuroprotective actions, holding promise for therapeutic insights into neuroinflammation.
Authors
- Yuwen Wen (ORCID: https://orcid.org/0000-0003-2959-9734)
- Wenru Su (ORCID: https://orcid.org/0000-0002-0506-6362)
- Yehong Zhuo (ORCID: https://orcid.org/0000-0003-3247-7199)
- Xiuxing Liu (ORCID: https://orcid.org/0000-0001-5855-6624)
- Caibin Deng (ORCID: https://orcid.org/0000-0001-7663-661X)
- Yanan Dou
- Zhenlan Yang (ORCID: https://orcid.org/0000-0001-9815-7142)
- Zhidong Li (ORCID: https://orcid.org/0000-0003-3288-5547)
- Ye Deng
- Xiaohong Chen
- Yingting Zhu
Institutions
- Sun Yat-sen University (CN)
- Shanghai Ninth People's Hospital (CN)
- Xijing Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1186/s12974-026-03838-8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province