Cooling inflammation through metabolism with 4-octyl itaconate
Itaconate is an immunomodulatory metabolite that links metabolism and inflammation. Li et al. uncover a mechanism by which itaconate and 4-octyl itaconate suppress cytokine signaling through the alkylation of tyrosine kinase 2 and Janus kinase 1. This study reveals a direct metabolic control of inflammation and highlights its therapeutic potential in sepsis.
Authors
- Thekla Cordes (ORCID: https://orcid.org/0000-0002-8097-191X)
- Hanna F Voß-Willenbockel
Institutions
- Helmholtz Centre for Infection Research (DE)
- Technische Universität Braunschweig (DE)
Publication Details
- Journal
- Trends in Immunology
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.it.2026.04.004
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Boehringer Ingelheim Stiftung