A Near-Infrared Photoactivatable, Brain-Penetrant Prodrug of the Prolyl Hydroxylase Inhibitor Vadadustat for Neuroprotection in Ischemic Stroke
reduced infarct volume and brain edema, and promoted neurological recovery. These findings highlight a photoactivatable, brain-penetrant prodrug strategy for spatiotemporally controlled neuroprotection.
Authors
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Wenxuan Wang (ORCID: https://orcid.org/0009-0009-8575-5210)
- Jihong Xing (ORCID: https://orcid.org/0000-0002-6472-9517)
- Tiande Bing
- Zhihong Li
- Ke Li
- Yikai Mo
- Yue Wu
- Danni Ao
- Fulai Yang
- Le Yang
Institutions
- China Pharmaceutical University (CN)
- Jilin University (CN)
- Applied Optimization (United States) (US)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c01014
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Jiangsu Province
- Fundamental Research Funds for the Central Universities