Pd‐Catalyzed Domino Heck‐Cyanation of Alkene‐Tethered Carbamoyl Chlorides With Zn(CN) <sub>2</sub>
ABSTRACT We report a Pd‐catalyzed domino Heck‐cyanation of alkene‐tethered carbamoyl chlorides with Zn(CN) 2 . This method provides cyano‐functionalized oxindoles in good to excellent yields. The strategy extends to cyanomethylated and thiocyanated oxindoles and demonstrates practical utility in the formal synthesis of bioactive molecules.
Authors
- Chunjie Ni (ORCID: https://orcid.org/0000-0003-1479-5484)
- Bingxiao Li (ORCID: https://orcid.org/0000-0002-0693-4985)
- Zhao Heng-yi
- Zi-Yi Wang
- Chen Chen (ORCID: https://orcid.org/0000-0002-5388-9611)
- Junjie Pan
- Xin‐Yu Hu
Institutions
- Tianjin Normal University (CN)
- Tianjin Chengjian University (CN)
- Yancheng Teachers University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2026-04-29
- DOI
- https://doi.org/10.1002/ajoc.70421
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province