Preoperative FAN score predicts survival outcomes after radical cystectomy for bladder cancer

Objective: This study aimed to evaluate whether the preoperative FAN score-composed of the fibrosis-4 (Fib-4) index, albumin-bilirubin (ALBI) score and neutrophil-lymphocyte ratio (NLR)-predicts recurrence-free, cancer-specific and overall survival after radical cystectomy for bladder cancer. Patients and Methods: We retrospectively analysed 1121 patients who underwent radical cystectomy at 13 institutions between April 2010 and March 2024. Associations between the FAN score and recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS) were evaluated. Prognostic performance was assessed in an independent cohort of 296 patients from three institutions. Results: < 0.0001). These associations were consistently observed in an independent cohort of 296 patients. Conclusions: The FAN score is an independent prognostic marker of adverse outcomes after radical cystectomy for bladder cancer and may help stratify patients for perioperative management and follow-up.

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Publication Details

Journal
BJUI Compass
Published
2026-04-30
DOI
https://doi.org/10.1002/bco2.70221
Primary Topic
Bladder and Urothelial Cancer Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Preoperative FAN score predicts survival outcomes after radical cystectomy for bladder cancer

Hiromu Horitani, Ken‐ichi Kakimoto, Hiroki Osaki, Shimpei Yamashita et al.
BJUI Compass
Bladder and Urothelial Cancer Treatments
article

Preoperative FAN score predicts survival outcomes after radical cystectomy for bladder cancer

Hiromu Horitani, Ken‐ichi Kakimoto, Hiroki Osaki, Shimpei Yamashita, Tsuyoshi Takada, Koji Hatano, Makoto Matsushita, Norio Nonomura, Atsunari Kawashima, Takuji Hayashi, Taigo Kato, Isao Hara, Takeshi Ujike, Takahiro Yoshida, Akira Nagahara, Yuta Oki, Tetsuya Takao, Toshichika Iwanishi, Osamu Miyake, Yasuo Kohjimoto, Yoshiyuki Yamamoto, Yu Ishizuya
article en

Abstract

Objective: This study aimed to evaluate whether the preoperative FAN score-composed of the fibrosis-4 (Fib-4) index, albumin-bilirubin (ALBI) score and neutrophil-lymphocyte ratio (NLR)-predicts recurrence-free, cancer-specific and overall survival after radical cystectomy for bladder cancer. Patients and Methods: We retrospectively analysed 1121 patients who underwent radical cystectomy at 13 institutions between April 2010 and March 2024. Associations between the FAN score and recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS) were evaluated. Prognostic performance was assessed in an independent cohort of 296 patients from three institutions. Results: < 0.0001). These associations were consistently observed in an independent cohort of 296 patients. Conclusions: The FAN score is an independent prognostic marker of adverse outcomes after radical cystectomy for bladder cancer and may help stratify patients for perioperative management and follow-up.

BJUI CompassVol. 7(5)
Wakayama Medical University (JP), Osaka Prefectural Medical Center (JP), Toyonaka Municipal Hospital (JP), Osaka National Hospital (JP), Ikeda Municipal Hospital (JP), Sakai Municipal Hospital (JP), Higashiosaka College & Higashiosaka Junior College (JP), Osaka Rosai Hospital (JP), Higashi Osaka City General Hospital (JP), Osaka Hospital (JP), Osaka International Cancer Institute (JP), Nippon Medical School Hospital (JP), Hyogo Prefectural Nishinomiya Hospital (JP), Minoh City Hospital (JP), The University of Osaka (JP)
Openalex Percentile: Top 12%
Bladder and Urothelial Cancer Treatments
DOIOpen Access PDFOpenAlex
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