Tailoring PRMT Inhibition: Shifting PRMT7 Selectivity to PRMT4 through “T-Shape” Strategy and “Linker-Specific” Preferences
= 2.6 nM). This approach highlights the potential of these design strategies to tune inhibitor selectivity, facilitating the development of isoform-specific PRMT inhibitors from existing scaffolds.
Authors
- Dattatraya P. Masal (ORCID: https://orcid.org/0000-0002-0111-4101)
- Nicholas Noinaj (ORCID: https://orcid.org/0000-0001-6361-2336)
- Akshay S. Kulkarni (ORCID: https://orcid.org/0000-0001-5612-5118)
- Youchao Deng (ORCID: https://orcid.org/0000-0003-1367-2677)
- Rong Huang (ORCID: https://orcid.org/0009-0004-7744-5435)
- Hye Seung Nam
- Marlyn Michelle Bush
- Tianqi Zhao
Institutions
- Purdue University West Lafayette (US)
- Drug Discovery Laboratory (Norway) (NO)
- Imation (United States) (US)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c01782
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Purdue University
- Purdue Institute for Drug Discovery
- National Institute of General Medical Sciences