Diversity of oligosaccharides in lipooligosaccharides of Akkermansia muciniphila and its anti-atherosclerotic activity
mice. The improvement of these metabolic symptoms was related to the restoration of intestinal barrier integrity. Mechanistically, ALOS upregulated the IL-23/IL-22 immune axis, which in turn promoted intestinal epithelial repair and modulates the microbiota. ALOS intervention reshaped the gut microbiota composition by enriching beneficial genera such as Bifidobacterium longum, Roseburia intestinalis, and Oscillibacter sp., while suppressing potential pathobionts. Our findings highlight the structural diversity and anti-atherosclerotic effect of lipooligosaccharides from A. muciniphila.
Authors
- Jingzu Sun (ORCID: https://orcid.org/0000-0003-1893-1869)
- Ruopeng Yin (ORCID: https://orcid.org/0000-0002-1195-418X)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-2358-0904)
- Wenzhao Wang (ORCID: https://orcid.org/0000-0001-5106-4862)
- Wang Dong (ORCID: https://orcid.org/0009-0005-6150-5082)
- Xun Lv
- Jinghan Lin
- Hongwei Liu
- Tao Wang
Institutions
- Chinese Academy of Sciences (CN)
- Institute of Mechanics (CN)
- Institute of Physics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Natural Products and Bioprospecting
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1007/s13659-026-00612-4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China