Evaluation of Antidiabetic Properties of a Polyherbal Extract (ACCBN) on Alloxan-induced Diabetic Rats

Diabetes mellitus emanates from a dysfunctional metabolic process and it affects human population globally, and causes a decline in the quality of life and increase in mortality rate due to its complications and adverse effects of the available antidiabetic drugs, thus, there is a need for a better antidiabetic agent. This study assessed the antidiabetic properties of a polyherbal extract (ACCBN) on alloxan-induced diabetic rats to validate its antidiabetic claims in traditional medicine. The diabetic study had 6 groups including normal control, diabetic rats deprived of treatment, diabetic rats administered 5 mg/kg Glibenclamide, and diabetic rats administered 400 and 800 mg/kg ACCBN-extract accordingly and normal rats administered 800 mg/kg ACCBN-extract only. The rats were successfully made diabetic by the administration of alloxan monohydrate intraperitoneally whereas and the rats were treated with either Glibenclamide or ACCBN-extract orally for 28 consecutive days. The acute study of ACCBN-extract indicated lethal dose above 5000 mg/kg. The diabetic rats deprived of treatment showed significantly elevated acute and sub-acute blood glucose levels including significantly elevated glycated haemoglobin concentration and significant decline in the C-peptide and insulin levels relative to the normal control. Diabetic rats administered ACCBN-extract displayed a marked decline in the acute and sub-acute blood glucose levels in comparison to the diabetic rats deprived of treatment. The diabetic rats administered ACCBN-extract displayed a remarkable decline in glycated haemoglobin level and significantly elevated C-peptide and insulin concentrations compared to the diabetic rats deprived of treatment. The outcome revealed that ACCBN-extract possesses sufficient antidiabetic properties and could be effective in the management of diabetes.