Precise borylation of targeted methyl group via an orderly chain-walking strategy
)-H borylation and affords a series of "Y-shape" boron analogs through rational desymmetric ligand design. This method exhibits broad substrate scope, good functional group tolerance, and high atom economy and achieves a chain-walking distance of 32 carbons, and we hope it will promote cross-disciplinary innovation in areas including materials science and pharmaceuticals.
Authors
- Yinwei Bao (ORCID: https://orcid.org/0009-0003-8288-8233)
- Yitao Wu (ORCID: https://orcid.org/0000-0002-6401-874X)
- Lu Zhan (ORCID: https://orcid.org/0000-0002-2988-1302)
- Feihe Huang (ORCID: https://orcid.org/0000-0003-3177-6744)
- Lixuan Zheng
- Chenke Hu
Institutions
- Zhejiang University of Science and Technology (CN)
- Zhejiang University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Science Advances
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1126/sciadv.aed6913
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Nanjing University
- State Key Laboratory of Coordination Chemistry
- Natural Science Foundation of Zhejiang Province