Novel Pathway for Intercepting Granular Exocytosis: <scp>A13</scp> Engages <scp>APLNR</scp> to Drive <scp>FBXO28</scp> ‐Mediated Ubiquitination and Proteasomal Clearance of Rab27a in Allergic Inflammation
cells. Intranasal A13 exhibits localised action, effectively suppressing allergic inflammation without broad systemic immunosuppression, making it a promising candidate for development as a topical biologic to treat allergic airway diseases.
Authors
- Qinmiao Huang
- Liu Y (ORCID: https://orcid.org/0009-0004-3901-1652)
- Jiaqi Duan
- Gaohui Wu (ORCID: https://orcid.org/0000-0002-2839-3112)
- Yanyu Ye
- Yun Liao
- Pingchang Yang
- Minyao Li
Institutions
- Shenzhen University (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Immunology
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1111/imm.70135
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Science, Technology and Innovation Commission of Shenzhen Municipality