Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation

Authors

Peiqi Xing (ORCID: https://orcid.org/0000-0002-5675-1036)
Pengcong Hou (ORCID: https://orcid.org/0009-0001-4779-8801)
J P Ye
Gang Bai (ORCID: https://orcid.org/0000-0001-9161-2173)
Yanni Ma (ORCID: https://orcid.org/0009-0006-4985-5036)
Xiangyu Chen (ORCID: https://orcid.org/0000-0001-7947-3211)
Z.H. Liu (ORCID: https://orcid.org/0000-0002-9199-6493)
Yang Zheng (ORCID: https://orcid.org/0000-0002-6793-3206)
Yuzhu Zhang (ORCID: https://orcid.org/0009-0000-3020-5486)
Yanjie Zhang (ORCID: https://orcid.org/0000-0001-9067-4583)
Jindou Xie
Liu R (ORCID: https://orcid.org/0000-0003-1034-1362)
Ruixin Jiang
Bin Jiang
Jing Huang
Robert L Judson-Torres
Hao Luo
Hanlin Zeng
A Hunter Shain
Ming Lei

Institutions

University of California, San Francisco (US)
Shanghai Jiao Tong University (CN)
Chinese Academy of Sciences (CN)
University of Utah (US)
Huntsman Cancer Institute (US)
Ruijin Hospital (CN)
Beijing Institute of Genomics (CN)
Shanghai Ninth People's Hospital (CN)
State Key Laboratory of Oncogene and Related Genes (CN)
Shanghai Center For Bioinformation Technology (CN)
University of Chinese Academy of Sciences (CN)
UCSF Helen Diller Family Comprehensive Cancer Center (US)

Publication Details

Journal: Science Advances
Published: 2026-05-01
DOI: https://doi.org/10.1126/sciadv.adz8289
Primary Topic: Melanoma and MAPK Pathways
Type: article
Field-Weighted Citation Impact: 0.00

Funders

GenScript
National Natural Science Foundation of China
National Key Research and Development Program of China

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article

Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation

Peiqi Xing, Pengcong Hou, J P Ye, Gang Bai et al.

May 1, 2026

Science Advances

Melanoma and MAPK Pathways

article

Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation

Peiqi Xing, Pengcong Hou, J P Ye, Gang Bai, Yanni Ma, Xiangyu Chen, Z.H. Liu, Yang Zheng, Yuzhu Zhang, Yanjie Zhang, Jindou Xie, Liu R, Ruixin Jiang, Bin Jiang, Jing Huang, Robert L Judson-Torres, Hao Luo, Hanlin Zeng, A Hunter Shain, Ming Lei

May 1, 2026article en

Abstract

No abstract available for this paper.

Science AdvancesVol. 12(18)

University of California, San Francisco (US), Shanghai Jiao Tong University (CN), Chinese Academy of Sciences (CN), University of Utah (US), Huntsman Cancer Institute (US), Ruijin Hospital (CN), Beijing Institute of Genomics (CN), Shanghai Ninth People's Hospital (CN), State Key Laboratory of Oncogene and Related Genes (CN), Shanghai Center For Bioinformation Technology (CN), University of Chinese Academy of Sciences (CN), UCSF Helen Diller Family Comprehensive Cancer Center (US)

GenScript, National Natural Science Foundation of China, National Key Research and Development Program of China

Openalex Percentile: Top 11%

Melanoma and MAPK Pathways

DOI Open Access PDF OpenAlex

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Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation — Peiqi Xing, Pengcong Hou, et al. · Science Advances (2026) | TGRS Research Map | TGRS