Diagnostic Dilemma of Signet‐Ring Like Cells on Retroperitoneal Mass Cytology

The morphology of a signet-ring can be imparted by a number of benign and malignant neoplasms. This poses a significant diagnostic pitfall in such cases, owing to deceptive cell cytology, scattered, scant cells, and the accumulation of large cytoplasmic mucin vacuoles, giving the characteristic 'signet ring cell appearance'. Herein, we present a case of embryonal carcinoma in the retroperitoneal region in a 13-year-old girl. Fine needle aspiration cytology can be misleading due to the presence of signet-ring-like cells. We present a rare case of embryonal carcinoma with signet-ring differentiation and its cytohistological correlation.

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Publication Details

Journal
Cytopathology
Published
2026-05-01
DOI
https://doi.org/10.1111/cyt.70083
Primary Topic
Ovarian cancer diagnosis and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Diagnostic Dilemma of Signet‐Ring Like Cells on Retroperitoneal Mass Cytology

Manjit Kaur Rana, Pallavi Saraf, Gargi Kapatia, Prashant Chhabra et al.
Cytopathology
Ovarian cancer diagnosis and treatment
article

Diagnostic Dilemma of Signet‐Ring Like Cells on Retroperitoneal Mass Cytology

Manjit Kaur Rana, Pallavi Saraf, Gargi Kapatia, Prashant Chhabra, Ankita Soni, Priyanka Sharma
article en

Abstract

The morphology of a signet-ring can be imparted by a number of benign and malignant neoplasms. This poses a significant diagnostic pitfall in such cases, owing to deceptive cell cytology, scattered, scant cells, and the accumulation of large cytoplasmic mucin vacuoles, giving the characteristic 'signet ring cell appearance'. Herein, we present a case of embryonal carcinoma in the retroperitoneal region in a 13-year-old girl. Fine needle aspiration cytology can be misleading due to the presence of signet-ring-like cells. We present a rare case of embryonal carcinoma with signet-ring differentiation and its cytohistological correlation.

Cytopathology
All India Institute of Medical Sciences (IN)
Gender equality
Openalex Percentile: Top 9%
Ovarian cancer diagnosis and treatment
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