A novel stereochemistry retention mechanism in the SN2 reaction
A recent study by Lu et al. reports the nucleophilic substitution reaction between Cl‒ and (CH3)3CI can proceed via a flip-over mechanism — a new type of SN2 pathway that retains configuration, discovered through simulations on a full-dimensional potential energy surface.
Authors
- Jing Xie (ORCID: https://orcid.org/0000-0001-9676-5734)
- Zhexuan Song
- Hong Gao (ORCID: https://orcid.org/0000-0002-9140-0063)
Institutions
- Beijing Institute of Technology (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1038/s41467-026-72120-5
- Primary Topic
- Chemical Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China