Clinical features, risk factors and outcomes of hydrocephalus in neonatal bacterial meningitis: a retrospective case–control study
/L as risk factors for hydrocephalus. The receiver operating characteristic results showed CSF WBC, CSF glucose, and protein levels on the second LP had predictive value for hydrocephalus. Neonates with hydrocephalus in BM had significantly higher ratios of hearing impairment (53.4%), encephalomalacia (39.7%), secondary epilepsy (37.0%), and death (8.2%) in the first two years of life (all P < 0.05). Together, these data demonstrated that high WBC and CSF protein levels on the second LP were predictors of hydrocephalus in neonatal BM. Hydrocephalus in BM was significantly associated with mortality and poor outcomes.
Authors
- Guohui Lu (ORCID: https://orcid.org/0000-0001-6713-0000)
- J P Li
- Meiling Huang (ORCID: https://orcid.org/0000-0002-8766-9510)
- Juncao Chen (ORCID: https://orcid.org/0000-0003-0579-1908)
- Weiming Yuan (ORCID: https://orcid.org/0000-0002-4780-7157)
- Haiyan Zhao (ORCID: https://orcid.org/0000-0002-7752-7308)
- Zhaoli Yu
- Jizhi Xu
- TingTing Cheng
Institutions
- Hunan Provincial Center for Disease Control and Prevention (CN)
- ShenZhen People’s Hospital (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Changsha Hospital for Maternal and Child Health Care (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1038/s41598-026-50052-w
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00