Challenging the GalNAc dogma: intrinsic LNP chemistry enables LDLR-independent hepatic delivery
Current dogma mandates GalNAc conjugation for LDLR-independent hepatocyte mRNA delivery. However, groundbreaking research from the Anderson and Dahlman labs, alongside Sanofi’s preclinical data, reveals that optimizing internal LNP architecture robustly bypasses the LDLR without complex surface ligands, streamlining future hepatic genetic medicines.
Authors
- Arnab Rudra (ORCID: https://orcid.org/0000-0002-1704-5534)
Institutions
- Boston Children's Hospital (US)
Publication Details
- Journal
- Nucleic Acid Insights
- Published
- 2026-04-22
- DOI
- https://doi.org/10.18609/nuc.2026.021
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00