Generation of four human induced pluripotent stem cell lines derived from patients with corticosteroid-associated central serous chorioretinopathy
Peripheral blood from four male patients with corticosteroid-related central serous chorioretinopathy (CSC) was used to generate human induced pluripotent stem cells (hiPSCs). Non-integrating episomal vectors were employed to deliver the reprogramming factors. All hiPSCs displayed typical morphology, expressed markers of the undifferentiated state, demonstrated the ability to differentiate into the three-germ layers, and exhibited normal karyotypes. These hiPSC lines offer a valuable model to study CSC pathogenesis.
Authors
- Onno Cornelis Meijer (ORCID: https://orcid.org/0000-0002-8394-6859)
- Joost Brinks (ORCID: https://orcid.org/0000-0002-2649-8199)
- Christian Freund (ORCID: https://orcid.org/0000-0001-7416-8226)
- Karine Raymond (ORCID: https://orcid.org/0000-0001-5892-8117)
- Sekar Galuh (ORCID: https://orcid.org/0000-0002-0053-3603)
- Elon H C van Dijk
- Camiel J F Boon
Institutions
- Loyola University Medical Center (US)
- Inserm (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Leiden University Medical Center (NL)
- CEA Grenoble (FR)
- Rotterdam Eye Hospital (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1016/j.scr.2026.104006
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw
- Algemene Nederlandse Vereniging ter voorkoming van Blindheid
- Landelijke Stichting voor Blinden en Slechtzienden
- Stichting voor Ooglijders
- Rotterdamse Stichting Blindenbelangen
- Stichting Blinden-Penning
- Stichting Leids Oogheelkundig Ondersteuningsfonds