Probiotic Bacillus licheniformis competitively establishes and enhances production efficiency, immune responsiveness, and protection against Aeromonas hydrophila O:18 in Cirrhinus mrigala (Ham.)
, B. licheniformis significantly improved both cellular immune responses (phagocytic index and ratio, respiratory burst activity, serum myeloperoxidase activity, ALP, and total leukocyte counts) and humoral (including adaptive) immune responses (lysozyme activity, serum bactericidal activity, serum haemagglutination titre, and natural haemolysin titre), as well as survival following challenge with A. hydrophila O:18. These findings support the potential use of this bacterial species as a probiotic candidate in diets for the culture of C. mrigala.
Authors
- Md Aklakur (ORCID: https://orcid.org/0000-0003-1633-4411)
- R. S. Dalvi (ORCID: https://orcid.org/0000-0003-3517-0184)
- Nilesh Pawar
- S. B. Jadhao (ORCID: https://orcid.org/0000-0003-2859-8529)
- Rajive Kumar Brahmchari (ORCID: https://orcid.org/0000-0003-2241-1911)
- Ranjit Kumar Nadella (ORCID: https://orcid.org/0000-0002-0239-8652)
- Mukesh Singh (ORCID: https://orcid.org/0000-0003-1166-2619)
- Ram Prakash Raman (ORCID: https://orcid.org/0000-0002-0215-1019)
- Shruti Gupta
- Md Imran Shah
Institutions
- Central Institute of Fisheries Technology (IN)
- University of Mumbai (IN)
- Dr. Rajendra Prasad Central Agriculture University (IN)
- Indian Institute of Science Education and Research, Bhopal (IN)
- Department of Animal Husbandry (IN)
- Central Institute of Fisheries Education (IN)
- Central Agricultural University (IN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1038/s41598-026-41166-2
- Primary Topic
- Aquaculture disease management and microbiota
- Type
- article
- Field-Weighted Citation Impact
- 0.00