Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review
-acetylcysteine was investigated in two clinical trials and one RCT and was minimally effective in the RCT and in one clinical study. Our review did not identify available studies of local alternative otoprotective agents that could reliably replace systemic STS in terms of safety and efficacy for pediatric patients. Further research on the optimal dosage, delivery method, and timing of otoprotective agents is needed.
Authors
- Vassilios Papadakis (ORCID: https://orcid.org/0000-0002-1821-7799)
- Brice Fresneau (ORCID: https://orcid.org/0000-0001-7603-7828)
- Penelope Brock (ORCID: https://orcid.org/0000-0003-1239-6316)
- Rudolf Maibach (ORCID: https://orcid.org/0000-0002-4297-8969)
- Archie Bleyer (ORCID: https://orcid.org/0000-0001-7738-5146)
- Martine van Grotel (ORCID: https://orcid.org/0000-0002-8849-8573)
- Éric Bouffet (ORCID: https://orcid.org/0000-0002-6832-6539)
- Michael Sullivan (ORCID: https://orcid.org/0000-0002-8606-5889)
- Allison F. O’Neill (ORCID: https://orcid.org/0000-0002-8957-3870)
- Kaukab Rajput (ORCID: https://orcid.org/0000-0002-6155-9372)
- James I. Geller (ORCID: https://orcid.org/0000-0001-5181-116X)
- Per Kogner (ORCID: https://orcid.org/0000-0002-2202-9694)
- Gareth J. Veal (ORCID: https://orcid.org/0000-0002-1897-8678)
- Nienke Streefkerk (ORCID: https://orcid.org/0009-0001-3362-6953)
- Amirhossein Masroor
- Alwin D R Huitema
- Kristin Knight
- Marc Ansari
- Marry M Van Den Heuvel-Eibrink
- Alexander E Hoetink
Institutions
- University of Geneva (CH)
- Royal Children's Hospital (AU)
- Karolinska University Hospital (SE)
- Inserm (FR)
- Oregon Health & Science University (US)
- Utrecht University (NL)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- Hospital for Sick Children (CA)
- Institut Gustave Roussy (FR)
- University Medical Center Utrecht (NL)
- University of California San Diego (US)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Center for Cancer and Blood Disorders (US)
- Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL)
- Princess Máxima Center (NL)
- Foundation Medical Partners (US)
- Iaso Children’s Hospital (GR)
- Wilhelmina Children's Hospital (NL)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- Geneva College (US)
- University of Newcastle Australia (AU)
- Newcastle University (GB)
Publication Details
- Journal
- Drug Delivery
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1080/10717544.2026.2665892
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stichting Kinderen Kankervrij