Design of Experiments‐assisted Micellar Electrokinetic Chromatography Separation of Phosphodiesterase‐5 Inhibitors: Application to Sildenafil and Tadalafil
of 4.75 and migration times below 6 min. The method was validated in terms of precision, linearity, accuracy, and robustness, showing satisfactory analytical performance. Application to pharmaceutical formulations and dietary supplement samples confirmed the suitability of the proposed method for routine screening and quality control purposes.
Authors
- Valentin Ion (ORCID: https://orcid.org/0000-0002-4501-8365)
- Cristina Niculas (ORCID: https://orcid.org/0000-0003-2879-5813)
- Anca Cârje (ORCID: https://orcid.org/0000-0001-8044-3036)
- Gabriel Hancu (ORCID: https://orcid.org/0000-0003-2564-9271)
- Daniela Lucia Muntean
- Zoltán István Szabó
Institutions
- Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș (RO)
Publication Details
- Journal
- Journal of Separation Science
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1002/jssc.70429
- Primary Topic
- Pharmaceutical Quality and Counterfeiting
- Type
- article
- Field-Weighted Citation Impact
- 0.00