Repurposing drug screen for the identification of helicase inhibitors from viruses of pandemic concern
) in cells. Overall, we developed several high-throughput assays for antiviral drug screening against viral helicases and identified several lead scaffolds that may provide much needed tools to address future pandemics and endemic diseases with few treatment options.
Authors
- Judd F. Hultquist (ORCID: https://orcid.org/0000-0001-6424-4280)
- Elizabeth Gleason
- Gilles Degotte (ORCID: https://orcid.org/0000-0001-6318-4626)
- Taha Y. Taha (ORCID: https://orcid.org/0000-0002-7344-7490)
- Adam R. Renslo (ORCID: https://orcid.org/0000-0002-1240-2846)
- Margarita Rzhetskaya
- Luca Lizzadro
- Nicole L. Inniss (ORCID: https://orcid.org/0000-0002-1510-7412)
- Julia Rosecrans (ORCID: https://orcid.org/0009-0000-3111-5933)
- Kelly E R Bachta
- Francisco J. Zapatero-Belinchón
- Karla J Satchell
- Ryan P Kich
- Melanie Ott
- Valentina Pedrero-Classen
- George Minasov
- Kenneth Huang (ORCID: https://orcid.org/0009-0006-2257-2837)
- Jason Pattie
Institutions
- Northwestern University (US)
- Gladstone Institutes (US)
- University of California, San Francisco (US)
Publication Details
- Journal
- SLAS DISCOVERY
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.slasd.2026.100311
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gladstone Institutes
- Roddenberry Foundation
- James B. Pendleton Charitable Trust
- Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases