British Society for Rheumatology guideline for the management of children, young people and adults with systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a lifelong autoimmune condition with multi-system involvement that is associated with morbidity, mortality, and poor quality of life. The key aim of management should be to empower individuals with SLE to manage their condition, suppressing systemic disease activity, and preventing organ damage. This guideline builds on and expands the recommendations developed for the first guideline published in 2017 for adults living with SLE. This comprehensive life-course guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Working Group (GWG) comprising healthcare professionals with expertise in paediatric and adult SLE, and people with lived experience. The GWG reviewed published guidelines, undertook a systematic literature review and utilised expertise from specialist lupus centres across the UK and patient representatives to formulate a list of 102 recommendations with corresponding strength of recommendations and agreement scores. These recommendations encompass advances in the assessment, diagnosis, monitoring, general approaches to management, non-pharmacological and pharmacological management of SLE, organ-specific treatment including lupus nephritis and cutaneous lupus erythematosus, as well as the delivery of care in the context of the UK healthcare system. Furthermore, we have provided research and audit recommendations to support equitable access to care and improve health outcomes in SLE.

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Journal
University of Birmingham Research Portal (University of Birmingham)
Published
2026-04-20
Primary Topic
Systemic Lupus Erythematosus Research
Type
article
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article

British Society for Rheumatology guideline for the management of children, young people and adults with systemic lupus erythematosus

Kalveer Flora, Arvind Kaul, Bridget Griffiths, Nadia Corp et al.
University of Birmingham Research Portal (University of Birmingham)
Systemic Lupus Erythematosus Research
article

British Society for Rheumatology guideline for the management of children, young people and adults with systemic lupus erythematosus

Kalveer Flora, Arvind Kaul, Bridget Griffiths, Nadia Corp, Rebecca Gilman, Lindsey Cherry, Heather Rostron, Antonios Psarras, L Lightstone, Dalila Tremarias, Jade Skeates, Elena Moraitis, Hanna Lythgoe, Clare Nash, Naomi Maxwell, D Isenberg, Natasha Jordan, Zoe McLaren, C H R I S T Mallen, Peter Lanyon, Clarissa Pilkington, Michael W. Beresford, Eve M. D. Smith, Md Yuzaiful Md Yusof, Stephen D. Marks, Ruth J. Pepper, Philip M. Laws, Caroline Gordon, Asad Zoma, Kate Armon, Danielle A. van der Windt, British Society for Rheumatology Guidelines Working Group members, Chris Wincup, Christopher J. Edwards, Edward M. Vital, Sarah Skeoch
article en

Abstract

Systemic lupus erythematosus (SLE) is a lifelong autoimmune condition with multi-system involvement that is associated with morbidity, mortality, and poor quality of life. The key aim of management should be to empower individuals with SLE to manage their condition, suppressing systemic disease activity, and preventing organ damage. This guideline builds on and expands the recommendations developed for the first guideline published in 2017 for adults living with SLE. This comprehensive life-course guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Working Group (GWG) comprising healthcare professionals with expertise in paediatric and adult SLE, and people with lived experience. The GWG reviewed published guidelines, undertook a systematic literature review and utilised expertise from specialist lupus centres across the UK and patient representatives to formulate a list of 102 recommendations with corresponding strength of recommendations and agreement scores. These recommendations encompass advances in the assessment, diagnosis, monitoring, general approaches to management, non-pharmacological and pharmacological management of SLE, organ-specific treatment including lupus nephritis and cutaneous lupus erythematosus, as well as the delivery of care in the context of the UK healthcare system. Furthermore, we have provided research and audit recommendations to support equitable access to care and improve health outcomes in SLE.

University of Birmingham Research Portal (University of Birmingham)
Nottingham University Hospitals NHS Trust (GB), University of Nottingham (GB), University of Liverpool (GB), Trinity College Dublin (IE), Aintree University Hospitals NHS Foundation Trust (GB), Chapel Allerton Hospital (GB), Leeds Teaching Hospitals NHS Trust (GB), Great Ormond Street Hospital for Children NHS Foundation Trust (GB), Royal Hospital for Children (GB), The Royal Free Hospital (GB), Freeman Hospital (GB), Northwick Park Hospital (GB), Hairmyres Hospital (GB), Cambridge University Hospitals NHS Foundation Trust (GB), University Hospital Southampton NHS Foundation Trust (GB), University of Oxford (GB), Manchester University NHS Foundation Trust (GB), Alder Hey Children's NHS Foundation Trust (GB), King's College Hospital NHS Foundation Trust (GB), Royal Hospital for Sick Children (GB), Sheffield Children's NHS Foundation Trust (GB), Oxford University Hospitals NHS Trust (GB), Alder Hey Children's Hospital (GB), Royal United Hospital Bath NHS Trust (GB), University of Southampton (GB), LUPUS UK, University College London (GB), Imperial College London (GB), Keele University (GB), University of Glasgow (GB), University of Birmingham (GB)
Good health and well-being
Openalex Percentile: Top 12%
Systemic Lupus Erythematosus Research
Open Access PDFOpenAlex
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