On the Role of Human-Precision Medicine Interaction in HCI-for-Health

Precision Medicine (PM) is increasingly adopted in clinical and consumer health contexts, with a growing body of HCI research engaging with PM-related technologies and practices. In this paper, we adopt a reflective and critical stance to examine how PM technologies may unsettle interactional assumptions commonly held in HCI-for-health. Building on recent discussions of Human-Precision Medicine Interaction (HPMI), we consider the role such a lens may play when probabilistic, model-derived evidence resists experience-based validation, when personalised prediction carries long-term psychological implications, and when trust and accountability are distributed across stakeholders. We identify five provocations that surface recurring interactional tensions in PM systems, alongside minimal criteria for recognising when HPMI-level attention may be needed. We outline a set of directions for HCI research in PM, and position these contributions as a basis for reconsidering how HCI engages with uncertainty, responsibility, and long-horizon health risks in data-driven medicine.