Relationship between plasma colloid osmotic pressure and 28-day all-cause mortality in ICU patients with sepsis: A retrospective study using the MIMIC-IV database

Plasma colloid osmotic pressure (PCOP) is crucial for regulating the exchange of fluids between the intravascular and extravascular compartments, as well as maintaining blood volume. PCOP has been noted in multiple studies to be involved in diseases linked to changes in vascular endothelial permeability. The study seeks to delve into the link between PCOP and clinical prognosis in critically ill patients with sepsis. Critically ill patients with sepsis, who required admission to the intensive care unit (ICU), were selected from the Medical Information Mart for Intensive Care IV database. The primary outcome of the study was all-cause mortality within 28 days. In total, 1651 ICU patients with sepsis were included. The average age was 65.86 ± 15.59 years. The 28-day all-cause mortality was 24.29%. Multivariate Cox proportional hazards regression analysis indicated that an increase in PCOP levels was associated to a decrease in all-cause mortality in the ICU (HR = 0.95, 95% confidence interval (CI): 0.92-0.98, P = .001) restricted cubic spline analysis demonstrated that when PCOP ≤ 16.258, an increase in PCOP was linked to a gradual decrease in 28-day all-cause mortality (HR = 0.88, 95% CI: 0.83-0.93, P < .001). PCOP is linked to 28-day all-cause mortality in ICU patients with sepsis. Within the cutoff value, sepsis patients with higher PCOP are associated with a lower risk of all-cause mortality within 28 days.