Gingipain proteases from the bacterium <i>Porphyromonas gingivalis</i> confer protection against airway viral infection
can significantly inhibit host IFN responses, its proteases preemptively reduce viral infectious capacity, protecting the host from severe damage associated with respiratory infections.
Authors
- Mark E. Peeples (ORCID: https://orcid.org/0000-0002-4582-317X)
- Barbara Potempa (ORCID: https://orcid.org/0000-0002-1226-6952)
- Marina Terekhova (ORCID: https://orcid.org/0000-0003-2925-3389)
- John D. Perpich (ORCID: https://orcid.org/0000-0002-7884-9202)
- Mitchell H. Grayson (ORCID: https://orcid.org/0000-0002-4673-2122)
- Phylip Chen (ORCID: https://orcid.org/0000-0001-6090-6320)
- Michelle Rohlfing
- Chandra L. Shrestha
- Katherine Carey
- Jan Potempa
- Maxim Artyomov
- Richard J Lamont
- Juhi Bagaitkar
- Carlos J Rodriguez Hernandez
- Alonso Cruz-Cruz
Institutions
- Nationwide Children's Hospital (US)
- University of Louisville (US)
- Sullivan University (US)
- The Ohio State University (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1073/pnas.2503100123
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Dental and Craniofacial Research