Prebiotic intervention changes host and microbe proteomes in plasma extracellular vesicles of Parkinson’s disease
= 0.72). Based on these findings, we suggest that: (1) a precision prebiotic mixture can modulate PD-associated proteomic signatures and (2) plasma EV proteomics may be a platform to capture these biological responses and to explore potential diagnostic and staging biomarkers in the context of microbiome-targeted interventions.
Authors
- Ali Keshavarzian (ORCID: https://orcid.org/0000-0002-7969-3369)
- Thaisa M. Cantu-Jungles (ORCID: https://orcid.org/0000-0001-8928-9717)
- S Li
- Faraz Bishehsari (ORCID: https://orcid.org/0000-0001-5644-2586)
- Christopher B. Forsyth (ORCID: https://orcid.org/0000-0003-4690-7751)
- Robin M. Voigt (ORCID: https://orcid.org/0000-0002-8010-0786)
- Phillip A. Engen (ORCID: https://orcid.org/0000-0002-5276-5174)
- Bruce R. Hamaker (ORCID: https://orcid.org/0000-0001-6591-942X)
- Maliha W. Shaikh
- Erika G Marques de Menezes
- Deepak Sharma
- Christopher G Goetz
- Philip J Norris
- Deborah A Hall
- Jeff Jones
Institutions
- California Institute of Technology (US)
- Rush University Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Purdue University West Lafayette (US)
- Pacific Research Institute (US)
- Vitalant (US)
- University of Houston (US)
- Rush University (US)
- Chicago State University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1038/s41598-026-50859-7
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health