Pd-Catalyzed Geminal Coupling for the Construction of Fused Polycycles and Natural Product Synthesis
methyl ester and xiamycin E, where the geminal heterocoupling forges the fused tricyclic core and provides advanced intermediates for subsequent target-oriented elaboration. Mechanistic studies support an autotandem pathway involving initial cross-coupling followed by oxidative cyclometalation. Collectively, these studies establish a useful method for the modular construction of fused 6/5/6 polycycles.
Authors
- Jingfu Zhang
- J Chen (ORCID: https://orcid.org/0009-0005-0877-1277)
- Xinchen Yang (ORCID: https://orcid.org/0009-0004-3141-7551)
- Chunlin Zhu
- Zhiyuan Shang
- Chao Li
- Zhen Liu
Institutions
- Academy of Medical Sciences (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Normal University (CN)
- Peking Union Medical College Hospital (CN)
- National Institute of Biological Sciences, Beijing (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1021/jacs.6c03383
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00