PDA@MnOx nanozyme-engineered mesenchymal stem cells for severe acute pancreatitis therapy via modulation of ROS-inflammation-microbiota homeostasis
nanozymes, MSCs, and the pathological microenvironment restored ROS-inflammation-microbiota homeostasis, significantly improving SAP outcomes. This study provides a multifunctional strategy integrating therapeutic efficacy, in vivo tracking, and gut microbiota modulation for SAP treatment.
Authors
- Tianxiao Mei
- Wenwen Jia (ORCID: https://orcid.org/0000-0001-5969-3751)
- Wenjun Le (ORCID: https://orcid.org/0000-0003-3972-1422)
- Fuguo Liu (ORCID: https://orcid.org/0000-0002-1645-0976)
- Chunxiu Dong
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Yihui Hu
- Muladili Mutailipu
- Liu Z
- Zinan Zhao
- Ran Cui
- Bo Chen
Institutions
- Tongji University (CN)
- Hubei University of Medicine (CN)
- Shanghai East Hospital (CN)
- Shanghai Cell Therapy Research Institute (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1186/s12951-026-04487-y
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China