How ketamine works: An actionable hypothesis
Ketamine has been shown to reduce depression and suicidality in individuals resistant to treatment by other drugs. Exactly how ketamine works is not known. Here, I propose a new hypothesis that involves synaptic and circuit plasticity and may lead to enhanced efficacy in treating depression as well as other conditions.
Authors
- Roberto Malinow (ORCID: https://orcid.org/0000-0002-8862-2562)
Institutions
- University of California San Diego (US)
- Institute of Neurobiology (BG)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1073/pnas.2533728123
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00