Ribosome dynamics during skeletal muscle repair and regeneration in mice and humans
mRNA increased transiently, followed by increased ribosomal DNA transcription, leading to elevated total RNA levels. Skeletal muscle-specific ribosomal protein paralog RPL3L was replaced by the ubiquitously expressed RPL3 during the initial phases of recovery, but this shift was reversed by day 28. A substantial transcriptomic response was observed in human muscle injury, with heavy emphasis on MYC-induced anabolism and inflammation. This supports a model in which MYC-driven changes in ribosomal content and composition form a core anabolic module in skeletal muscle repair, potentially representing a targetable axis to enhance recovery after muscle injury.
Authors
- Johanna T. Lanner (ORCID: https://orcid.org/0000-0002-1222-9473)
- Abraham Nilsson (ORCID: https://orcid.org/0000-0003-0256-008X)
- Emily Shorter (ORCID: https://orcid.org/0000-0001-9431-3742)
- Kevin A. Murach (ORCID: https://orcid.org/0000-0003-2783-7137)
- Toby L. Chambers (ORCID: https://orcid.org/0000-0001-7567-1819)
- Ferdinand von Walden (ORCID: https://orcid.org/0000-0003-1134-2252)
- Jörg Schilcher (ORCID: https://orcid.org/0000-0003-0677-9265)
- Eva Pontén (ORCID: https://orcid.org/0000-0001-5228-1914)
- Ronald G. Jones
- Paulo R. Jannig
- Sebastian Edman (ORCID: https://orcid.org/0000-0003-2921-833X)
- Thomas Sejersen (ORCID: https://orcid.org/0000-0001-5961-7097)
- Minying Cui
- Oscar Horwath
- Baptiste Jude
- Pieter J Koopmans
Institutions
- Linköping University (SE)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Swedish School of Sport and Health Sciences (SE)
- Linköping University Hospital (SE)
- Cytoskeleton (United States) (US)
- University of Arkansas at Fayetteville (US)
Publication Details
- Journal
- American Journal of Physiology-Cell Physiology
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1152/ajpcell.00184.2026
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00