Precision indole skeletal editing for single-carbon replacement
C-labeled carbon into the scaffold. We highlighted the practical applicability of this method through a concise four-step total synthesis of quebrachamine, a complex monoterpene indole alkaloid. Experimental studies and density functional theory (DFT) calculations revealed a reaction pathway involving cascade [2+2] cycloaddition, retro-[2+2] ring opening, decarbonylation, and cyclization, elucidating the sequence at an atomic level.
Authors
- Huiying Zeng (ORCID: https://orcid.org/0000-0002-2535-111X)
- Yatao Lang
- Xinlong Han (ORCID: https://orcid.org/0009-0003-5676-080X)
- Zhen Luo
- Ling Zhang
- Chao-Jun Li
Institutions
- Centre in Green Chemistry and Catalysis (CA)
- Lanzhou University (CN)
Publication Details
- Journal
- Science
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1126/science.aec3587
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cietvielu Fizikas Institūts, Latvijas Universitate
- National Natural Science Foundation of China
- Fonds Québécois de la Recherche sur la Nature et les Technologies
- Natural Sciences and Engineering Research Council of Canada
- FP7 Joint Research Centre