Origins and drivers of self‐reactive B cells in autoimmune disease
Self-reactive B cells are a hallmark of autoimmune disease and may directly contribute to disease pathogenesis. This Research Highlight article reviews four articles published in 2025 that offer new insights into the origins and drivers of self-reactive B cells. These studies investigate self-reactive B cells in human peripheral blood, murine models, and the role of viral and genetic drivers.
Authors
- Joanne H. Reed (ORCID: https://orcid.org/0000-0002-7585-7848)
- Adrian Y S Lee
- Qian Shen
Institutions
- The University of Sydney (AU)
- Westmead Hospital (AU)
- Westmead Institute for Medical Research (AU)
Publication Details
- Journal
- Immunology and Cell Biology
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1111/imcb.70128
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Rebecca L. Cooper Medical Research Foundation
- National Health and Medical Research Council