Cobalt-Catalyzed Asymmetric Annulative Dienylation with Allenyl Carbinol Acetates via Desymmetrization
desymmetrization is reported. The method affords valuable C1-chiral 3-styryl-1,2-dihydroisoquinolines in high yields with excellent enantioselectivities. It is operationally simple and scalable, exhibits broad substrate generality, and is also effective for accessing P-stereogenic cyclic phosphinamides.
Authors
- Suman Ghosh (ORCID: https://orcid.org/0009-0004-1831-374X)
- Mainak Koner
- Mahiuddin Baidya (ORCID: https://orcid.org/0000-0001-9415-7137)
Institutions
- Indian Institute of Technology Madras (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1021/acs.orglett.6c01285
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Council of Scientific and Industrial Research, India
- Ministry of Education, India
- Science and Engineering Research Board