Flexible Dual-Apt Scaffolds Reveal gPD-L1-sEVs in Breast Cancer
< 0.0001), with high specificity and reproducibility. This work overcomes the technical bottleneck of glycosylation interference in gPD-L1 detection, establishes a new liquid-biopsy paradigm for gPD-L1-sEV detection, and provides a reliable tool for predicting ICB efficacy in breast cancer, thus laying a critical foundation for personalized immunotherapy.
Authors
- Pingyun Li (ORCID: https://orcid.org/0000-0002-5025-7598)
- Linxi Lv (ORCID: https://orcid.org/0000-0003-2051-1206)
- Hui Xiao
- Xiaopei Qiu
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Xinlin Guo
- Zhengheng Yu
- Jie Xie
- Xiaoxing Wang
- Tian Wang
- Fei Yang
- Yang Luo
- Hong Zhang
- Wei Gu
- Peijun Xu
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Chongqing University (CN)
- Kunming Medical University (CN)
- Ministry of Education (TH)
- Chongqing Emergency Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1021/acs.analchem.6c01173
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing