Comparative safety of direct oral anticoagulants and low-molecular-weight heparin in patients with venous thromboembolism and cancer in Europe
These findings suggest that apixaban may offer a safer bleeding profile than LMWH for patients with cancer-associated VTE, particularly in reducing overall and other types of bleeding. Rivaroxaban also appears to be a viable alternative to LMWH, with a notably lower risk of ICH. These results provide valuable real-world insights in an area where evidence remains very limited and support the role of DOACs as a safe alternative to LMWH in patients with VTE and cancer.
Authors
- Alison Booth (ORCID: https://orcid.org/0000-0002-7977-9621)
- Moritz Lehne (ORCID: https://orcid.org/0000-0001-8435-1374)
- Annie Young (ORCID: https://orcid.org/0000-0001-6611-6653)
- Marco Ghiani (ORCID: https://orcid.org/0000-0002-5827-6822)
- Sophie Graham (ORCID: https://orcid.org/0000-0002-7770-1863)
- Ellen Brodin
- Anders Gottsäter (ORCID: https://orcid.org/0000-0003-0865-0000)
- Daniela Fliegner
- Antje Mevius (ORCID: https://orcid.org/0000-0002-9556-6693)
- Dimitra Lambrelli (ORCID: https://orcid.org/0000-0002-2430-1778)
- Raza Alikhan (ORCID: https://orcid.org/0000-0001-8762-1149)
- Ruth Mokgokong (ORCID: https://orcid.org/0000-0002-6278-4969)
- José Chaves (ORCID: https://orcid.org/0000-0003-3820-3009)
- Lauri Timo
- Rupesh Subash
- Florian Langer
- Feng Dai
- Aaron Jenkins (ORCID: https://orcid.org/0000-0001-9785-9388)
- Beth Nordstrom (ORCID: https://orcid.org/0000-0003-1743-9610)
Institutions
- Ithaka Harbors (US)
- Wismar University of Applied Sciences (DE)
- Pfizer (United States) (US)
- Malmö University (SE)
- Pfizer (United Kingdom) (GB)
- Oulu University Hospital (FI)
- Akershus University Hospital (NO)
- University of Warwick (GB)
- Pfizer (Germany) (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Skåne University Hospital (SE)
- Pfizer (Spain) (ES)
- Cardiff University (GB)
- Cytel (United States) (US)
- University of Wales (GB)
Publication Details
- Journal
- Journal of Comparative Effectiveness Research
- Published
- 2026-05-01
- DOI
- https://doi.org/10.57264/cer-2025-0072
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00