Nucleobase Coordination With Mg <sup>2</sup> <sup>+</sup> Facilitates RNA Cleavage via Internal Transesterification

of rA, leading to lower activation barriers and faster cleavage kinetics, thereby rationalizing the preferential alkali-catalyzed RNA cleavage at pyrimidine sites. These findings uncover a previously unrecognized mechanistic role of nucleobases in RNA backbone scission and provide new insights into spontaneous RNA degradation and RNase- and ribozyme-catalyzed RNA cleavage.

Authors

Shiqing Huang (ORCID: https://orcid.org/0000-0002-6377-368X)
Y G Liu
Kuan Lu
Chuanzheng Zhou (ORCID: https://orcid.org/0000-0002-0811-7794)
Haitao Zhang (ORCID: https://orcid.org/0000-0002-1639-4089)
Zhilei Yu
Hai Hang
Yifei Zhou

Institutions

Nankai University (CN)
Renmin University of China (CN)

Publication Details

Journal: Chemistry - A European Journal
Published: 2026-04-30
DOI: https://doi.org/10.1002/chem.71102
Primary Topic: RNA and protein synthesis mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Natural Science Foundation of China
Natural Science Foundation of Tianjin City
National Key Research and Development Program of China

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article

Nucleobase Coordination With Mg ² ⁺ Facilitates RNA Cleavage via Internal Transesterification

Shiqing Huang, Y G Liu, Kuan Lu, Chuanzheng Zhou et al.

Apr 30, 2026

Chemistry - A European Journal

RNA and protein synthesis mechanisms

article

Nucleobase Coordination With Mg ² ⁺ Facilitates RNA Cleavage via Internal Transesterification

Shiqing Huang, Y G Liu, Kuan Lu, Chuanzheng Zhou, Haitao Zhang, Zhilei Yu, Hai Hang, Yifei Zhou

April 30, 2026article en

Abstract

of rA, leading to lower activation barriers and faster cleavage kinetics, thereby rationalizing the preferential alkali-catalyzed RNA cleavage at pyrimidine sites. These findings uncover a previously unrecognized mechanistic role of nucleobases in RNA backbone scission and provide new insights into spontaneous RNA degradation and RNase- and ribozyme-catalyzed RNA cleavage.

Chemistry - A European Journal

Nankai University (CN), Renmin University of China (CN)

National Natural Science Foundation of China, Natural Science Foundation of Tianjin City, National Key Research and Development Program of China

Openalex Percentile: Top 12%

RNA and protein synthesis mechanisms

DOI Source OpenAlex

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