From pancreas and islet resources to diabetes insights

Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the development of novel therapeutics. However, for decades, very few laboratories had access to this critical resource and experiments on human islets were typically underpowered. More recently, multiple consortia around the world have started to enable islet biology at scale, enriching our understanding of the intra-individual variability of islet function and disease mechanisms. This article reviews and compares existing large-scale human islet tissue and data resources, offering suggestions for their improvement and for developing new resources.

Authors

Institutions

Publication Details

Journal
Diabetologia
Published
2026-05-01
DOI
https://doi.org/10.1007/s00125-026-06731-4
Primary Topic
Pancreatic function and diabetes
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

From pancreas and islet resources to diabetes insights

Piero Marchetti, Patrick Edward MacDonald, Lorella Marselli, Sarah J. Richardson et al.
Diabetologia
Pancreatic function and diabetes
article

From pancreas and islet resources to diabetes insights

Piero Marchetti, Patrick Edward MacDonald, Lorella Marselli, Sarah J. Richardson, Jianguo Xia, Jonas Lemvig, James D. Johnson, Jesper G S Madsen, Teresa Rodriguez-Calvo, Christiana Lekka, Miriam Cnop, Xiaoyan Yi, Sing-Young Chen
article en

Abstract

Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the development of novel therapeutics. However, for decades, very few laboratories had access to this critical resource and experiments on human islets were typically underpowered. More recently, multiple consortia around the world have started to enable islet biology at scale, enriching our understanding of the intra-individual variability of islet function and disease mechanisms. This article reviews and compares existing large-scale human islet tissue and data resources, offering suggestions for their improvement and for developing new resources.

Diabetologia
University of Pisa (IT), Université Libre de Bruxelles (BE), University of British Columbia (CA), University of Alberta (CA), University of Southern Denmark (DK), Lund University (SE), University of Exeter (GB), Erasmus Hospital (BE), Michigan Medicine (US), Walloon Excellence in Lifesciences and Biotechnology (BE), German Center for Diabetes Research (DE), McGill University (CA)
Diabetes Canada, Novo Nordisk Fonden, Canadian Institutes of Health Research
Industry, innovation and infrastructure
Openalex Percentile: Top 13%
Pancreatic function and diabetes
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

From pancreas and islet resources to diabetes insights — Piero Marchetti, Patrick Edward MacDonald, et al. · Diabetologia (2026) | TGRS Research Map | TGRS