Hepatic rupture complicating HELLP syndrome in a low-resource setting: a case report

Spontaneous hepatic rupture is a rare but life-threatening complication of Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, associated with high maternal and perinatal mortality. Its diagnosis is challenging due to a nonspecific clinical presentation and limited diagnostic resources in low-resource settings. We report a 35-year-old woman who claims 7 months of amenorrhea with the diagnosis of severe preeclampsia and HELLP syndrome, who developed sudden right upper quadrant pain and hemodynamic instability. The bedside ultrasound showed hemoperitoneum and a ruptured subcapsular hematoma. Emergency laparotomy confirmed hepatic rupture, and hemostasis was achieved with surgical intervention. This case highlights the importance of maintaining a high index of suspicion for hepatic rupture in patients with HELLP syndrome presenting with acute abdominal pain. Timely diagnosis and surgical management are critical to improving maternal outcomes.

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Publication Details

Journal
BMC Pregnancy and Childbirth
Published
2026-04-30
DOI
https://doi.org/10.1186/s12884-026-09175-1
Primary Topic
Pregnancy and preeclampsia studies
Type
article
Field-Weighted Citation Impact
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article

Hepatic rupture complicating HELLP syndrome in a low-resource setting: a case report

mihiretu tesfamariam goshu, Ephrem Kedir
BMC Pregnancy and Childbirth
Pregnancy and preeclampsia studies
article

Hepatic rupture complicating HELLP syndrome in a low-resource setting: a case report

mihiretu tesfamariam goshu, Ephrem Kedir
article en

Abstract

Spontaneous hepatic rupture is a rare but life-threatening complication of Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, associated with high maternal and perinatal mortality. Its diagnosis is challenging due to a nonspecific clinical presentation and limited diagnostic resources in low-resource settings. We report a 35-year-old woman who claims 7 months of amenorrhea with the diagnosis of severe preeclampsia and HELLP syndrome, who developed sudden right upper quadrant pain and hemodynamic instability. The bedside ultrasound showed hemoperitoneum and a ruptured subcapsular hematoma. Emergency laparotomy confirmed hepatic rupture, and hemostasis was achieved with surgical intervention. This case highlights the importance of maintaining a high index of suspicion for hepatic rupture in patients with HELLP syndrome presenting with acute abdominal pain. Timely diagnosis and surgical management are critical to improving maternal outcomes.

BMC Pregnancy and Childbirth
Hawassa University (ET)
Openalex Percentile: Top 10%
Pregnancy and preeclampsia studies
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