Clinical Outcomes of Bail-Out Stenting After Drug-Coated Balloon Angioplasty: The International Multicenter BAILOUT Registry
BACKGROUND: Drug-coated balloons (DCBs) are increasingly adopted in percutaneous coronary intervention. Bail-out drug-eluting stent (DES) implantation due to suboptimal immediate results after DCB angioplasty is not infrequent, and the clinical outcomes of percutaneous coronary intervention with DCB angioplasty followed by bail-out DES implantation remain unexplored. The aim of this study was to evaluate the safety of bail-out DES implantation following DCB angioplasty in percutaneous coronary intervention. METHODS: The BAILOUT registry included consecutive patients undergoing bail-out DES implantation after DCB angioplasty at 17 European centers between 2011 and 2024. The primary end point was target lesion failure (TLF) at 1 year, defined as the composite of target lesion revascularization, target vessel myocardial infarction, and cardiac death. The TLF rate was compared with a performance goal of 7.0% for an upfront DES-only strategy, derived from a meta-analysis of contemporary randomized controlled trials. RESULTS: =0.048). CONCLUSIONS: In cases of suboptimal angiographic results after DCB angioplasty, bail-out DES implantation is safe, with no increased risk of TLF at 1 year compared with the expected performance goal for an upfront DES-only strategy.
Authors
- Tuomas T. Rissanen (ORCID: https://orcid.org/0000-0002-1914-2282)
- Simon Eccleshall (ORCID: https://orcid.org/0000-0002-6395-2389)
- Elodi Bacci
- Ioannis Merinopoulos (ORCID: https://orcid.org/0000-0002-2059-0357)
- Kasper Kyhl (ORCID: https://orcid.org/0000-0001-6570-1674)
- Michele Galasso (ORCID: https://orcid.org/0009-0000-1603-4238)
- Alfonso Ielasi (ORCID: https://orcid.org/0000-0002-5982-1669)
- Marco FERRONE
- Michele Morosato (ORCID: https://orcid.org/0009-0005-7946-9382)
- Natasha Corballis (ORCID: https://orcid.org/0000-0002-6837-5787)
- Diego Arroyo
- Jonathan Hinton (ORCID: https://orcid.org/0000-0003-1670-5550)
- Francesca De Micco
- Thomas Johnson
- Gianmaria Calamita
- Marcello Marchetta (ORCID: https://orcid.org/0009-0005-1243-0600)
- Siamion Pismiankou
- Guido Vellucci
- F Ugo
- Giuseppe Massimo Sangiorgi
- S Galli
- M L Rossi
- D Maffeo
- C Briguori
- M Sabate
- D Regazzoli
- Mauro Chiarito
- Vassilios S Vassiliou
- Antonio Mangieri
- Pier Pasquale Leone
- Mauro Gitto
- Tullio Tesorio
- Luigi Salemme
- Kambis Mashayekhi
- Fernando Alfonso
- Peter O'Kane
- Giovanni Occhipinti
- Giulio G Stefanini
- Gabriele Gasparini
- Francesco Tartaglia
- Andrea Buono
- Antonio Colombo
- Azeem Latib
- Bernhard Reimers
Institutions
- University of Rome Tor Vergata (IT)
- Dorset HealthCare University NHS Foundation Trust (GB)
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- Humanitas University (IT)
- University of Fribourg (CH)
- Norfolk and Norwich University Hospital (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Zealand University Hospital (DK)
- Mercy Clinic Neurology (US)
- Centro Cardiologico Monzino (IT)
- North Karelia Central Hospital (FI)
- EMO GVM Centro Cuore Columbus (IT)
- Istituto Clinico Sant'Ambrogio (IT)
- CTO Andrea Alesini (IT)
- Clinica Mediterranea (IT)
- Hospital Universitario de La Princesa (ES)
- Fondazione Poliambulanza Istituto Ospedaliero (IT)
- Deutsches Herzzentrum München (DE)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Circulation Cardiovascular Interventions
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1161/circinterventions.125.016461
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00