Regioselective Oxidative Coupling of Monohalogenated Phenols
-tetramethylethylenediamine) clusters in 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP) under an air atmosphere at elevated temperatures. The scalable protocol enables, for the first time, direct access to 3,3'-, 4,4'-, and 5,5'-dihalo-2,2'-biphenols, providing entry to valuable synthetic intermediates for preparing complex biphenyl architectures.
Authors
- Doron Pappo (ORCID: https://orcid.org/0000-0002-8363-8709)
- Raja Kapanaiah
- Ratnadeep Bera
Institutions
- Ben-Gurion University of the Negev (IL)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1021/acs.orglett.5c05436
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- United States - Israel Binational Science Foundation
- Israel Science Foundation