Eudragit E100/silk fibroin hybrid nanoparticles for the controlled oral delivery of amphotericin B

AIMS: Amphotericin B (AmB) is the first-line antifungal compound for severe fungal infections, yet it possesses high renal toxicity, low water solubility, and acidic instability in the stomach. Herein, we developed novel nanoparticles from silk fibroin with/without Eudragit E100 (FNP and FNP/EE) for the controlled oral delivery of AmB. METHODS AND RESULTS: antifungal activity. CONCLUSIONS: The particles solved the AmB limitations by (1) protecting AmB from the gastric environment, (2) controlling AmB release, (3) reducing AmB toxicity, and (4) preserving AmB efficacy.