How Medically Important Antimicrobials Bind to the 30S Ribosomal Subunit in a Bacterial Pathogen
ribosomal 30S small subunit. For this, we used structural analogy, restrained energy minimization, and single-point binding free energy computations. We find the single-point binding free energy of the MIAs to be very sensitive to small conformational changes in the MIA and its environment. Incorporating this knowledge in structure-guided design could aid in the development of narrow-spectrum MIAs targeting specific bacterial pathogens.
Authors
- Swati R. Manjari (ORCID: https://orcid.org/0000-0002-3164-2300)
- Nilesh K. Banavali (ORCID: https://orcid.org/0000-0003-2206-7049)
- Caleb Mallery
Institutions
- Albany State University (US)
- New York State Department of Health (US)
- Albany College of Pharmacy and Health Sciences (US)
- University at Albany, State University of New York (US)
- Albany Research Institute (US)
Publication Details
- Journal
- Biochemistry
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1021/acs.biochem.6c00008
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute