Multi-region human miRNA target binding affinity atlas with m6A modulation flag

Closed-form multi-region atlas of human miRNA target binding affinity covering 3'UTR, 5'UTR, CDS, and lncRNA regions. 2,656 mature human miRNAs (miRBase v22) by 19,542 canonical human protein-coding transcripts (GENCODE v47), with region-appropriate biophysical weakening factors derived in closed form from cellular context (translation rate, scanning ribosome occupancy, cap-binding exclusion). m6A modulation flag via DRACH consensus motif scan (9.33M sites annotated). Coverage: 2,656 mature human miRNAs (full miRBase v22 hsa) across up to 5 transcript regions per pair (3'UTR, 5'UTR, CDS, lncRNA, circRNA), with per-site DRACH m6A overlap flag. CDS pipeline is the closed form ribosome displacement three state Markov chain steady-state correction; validation panel n=25 passes all three validation gates with median weakening 2.60x. 5'UTR pipeline is the closed-form scanning-ribosome displacement with shorter tau_occupy = 0.6 s and cap-proximity exclusion mask at d <= 40 nt; validation panel n=18 + 2 cap-proximity passes all four validation gates with median weakening 2.00x. 3'UTR pipeline validates at Pearson R = 0.847 against the 224-record Wee 2012 + Salomon 2015 single-molecule binding affinity panel and M.3 atlas validation AUC = 0.9339 multi-site / 0.8947 single-site against TarBase v9. Atlas SQLite (69.78 GB) is hosted externally at: https://atlas.coracleresearch.com/mirna_atlas_v3.sqlite SHA256: bc8c5ab614a5fab286239bf213e4210a9a62513c225403af7728bdf5f653d2ea This Zenodo deposit holds the bundle metadata, validation reports, and reproducibility scripts: - README.md (overview, validation tables, query patterns) - LICENSE (CC-BY-4.0) - CHANGELOG.md (v1 -> v2 -> v3 progression) - CITATION.cff (machine-readable citation) - clipseq_bench/ (CLIP-seq concordance bench: TSVs, JSON, figures, scripts) - drug_design_demo/ (5 clinical candidates: notebook, recovery TSVs, scripts) - query_atlas_v3.py (Python helper for atlas queries)