B-cell and plasma cell proliferations associated with T follicular helper cell lymphomas: clinical-pathological and genetic features
mutation was detected in 3 cases, most likely representing contamination by minor nTFHL clones. In conclusion, TFHL-associated B/PCP are a heterogeneous group of lymphoproliferative and plasma cell disorders, displaying recurrent histological patterns and frequent clonal hematopoiesis-associated mutations. Further studies on larger cohorts of patients are warranted to elucidate their biological and clinical implications.
Authors
- Francesco Piazza (ORCID: https://orcid.org/0000-0003-0205-3790)
- Federico Scarmozzino (ORCID: https://orcid.org/0000-0002-2571-5147)
- Laura Bonaldi (ORCID: https://orcid.org/0000-0001-7101-3093)
- Barbara Famengo
- Giorgio Alberto Croci (ORCID: https://orcid.org/0000-0001-5979-7841)
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Luisa Lorenzi (ORCID: https://orcid.org/0000-0003-2483-2955)
- Chiara Pagani (ORCID: https://orcid.org/0000-0002-6962-4466)
- B. Filippi
- Greta Scapinello
- Elena Sabattini (ORCID: https://orcid.org/0000-0002-4136-3591)
- Fabrizio Vianello (ORCID: https://orcid.org/0000-0002-7174-4651)
- Marco Angelo Cocchi
- Simona Righi (ORCID: https://orcid.org/0000-0003-3114-3998)
- Marco Pizzi (ORCID: https://orcid.org/0000-0003-4006-7317)
- Piera Balzarini (ORCID: https://orcid.org/0000-0003-2160-0999)
- Andrea De Crescenzo
- Elena Bellan (ORCID: https://orcid.org/0000-0003-3294-6055)
- Luisa Santoro
- A P Dei Tos
- Matteo Fusi
- Giulio Eugenio Mandelli
- Giorgia Caniato
- Francesco La Marra
Institutions
- University of Padua (IT)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Istituto Oncologico Veneto (IT)
- Azienda USL di Bologna (IT)
- Ospedale dell' Angelo (IT)
- Ospedale San Bortolo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1007/s00428-026-04530-1
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Padova